Tags: Drug.

Zileuton (trade name ZYFLO) is an orally active inhibitor of 5-lipoxygenase and thus inhibits leukotrienes (LTB4 LTC4 LTD4 and LTE4) formation. Zileuton is used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names ZYFLO and ZYFLO CR. The original immediate-release formulation of zileuton known as ZYFLO is taken four times per day.

(±)-Zileuton_Enantiomers_Structural_Formulae.png
ATC prefix
none
CAS number
111406-87-2
ChEBI
10112
DrugBank
DB00744
FDA UNII code
V1L22WVE2S
IUPAC name
N-​[1-​(1-​benzothien-​2-​yl)​ethyl]-​N-​hydroxyurea
PubChem
60490

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