Tags: Chemical Compound, Chemical Substance.

Saridegib also known as IPI-926 is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer including hard to treat hematologic malignancies such as myelofibrosis and ligand-dependant tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened a component of the hedgehog signaling pathway. Chemically it is a semi-synthetic derivative of the alkaloid cyclopamine.

Saridegib.svg
IUPAC name
N-((2S3R3aS3′R4a′R6S6a′R6b′S7aR12a&prmie;S12b′S)-3611′12b′-tetramethyl-2′3a3′44′4a′55&prmie;66′6a′6b′77a7′8′10′12′12a′12b′-icosahydro-1′H3H-spiro[furo[32-b]pyridine-29'-naphtho[21-a]azulen]-3'-yl)methanesulfonamide

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