Tags: Chemical Compound, Chemical Substance.
PF-4840154 is pyrimidine derivative discovered by Pfizer at its Sandwich Kent research centre. The compound is a potent selective activator of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel for in-vitro High-throughput screening purposes and is superior to allyl isothiocyanate for this use.
