Tags: Protein.
E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways.