Repulsive Guidance Molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa RGMb and RGMc (also called hemojuvelin).RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example RGMa helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion.
This page contains content from the copyrighted Wikipedia article "Repulsive guidance molecule"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.