Tags: Protein.
FK506 binding protein 6 also known as FKBP6 is a human gene. The encoded protein shows structural homology to FKBP immunophilins which bind to the immunosuppressants FK506 and rapamycin.FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in mice results in infertile males but apparently normal females. Rats with spermatogenic failure at meiosis were found to have a deletion in the exon 8 portion of the FKBP6 gene.
