Tags: Protein.
High affinity cAMP-specific and IBMX-insensitive 3’5′-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages and suggests that this protein may be required by HIV-1 for its replication.