PD 144418 or 1236-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor with a reported binding affinity of Ki = 0.08 ± 0.01 nM and 17 212 times selectivity over the sigma-2 receptor.
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