Tags: Drug.
NE-100 or 4-methoxy-3-(2-phenylethoxy)-NN-dipropylbenzeneethanamine is a selective sigma-1 receptor antagonist with a reported binding affinity of Ki = 1.03 ± 0.01 nM and more than 205 times selectivity over the sigma-2 receptor.NE-100 was one of the earliest selective sigma-1 receptor ligands reported and has been widely used as a pharmacological tool. The original eight step synthesis of NE-100 was reported by Atsuro Nakazato and colleagues of Taisho Pharmaceutical Company in 1999.
