Tags: Protein.
Paxillin is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge. The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions. It is presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction sites.