Tags: Protein.
SMAD family member 4 also known as SMAD4 is a protein that in humans is encoded by the SMAD4 gene.SMAD4 is a 552-amino acid protein involved in cell signaling. It belongs to the Darfwin family of proteins that modulate members of the TGFβ protein superfamily. It binds receptor-regulated SMADs such as SMAD1 and SMAD2 and forms a complex that binds to DNA and serves as a transcription factor. It is the only known mammalian coSMAD.