Tags: Protein.
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It mediates the signals from the transforming growth factor beta (TGF-β) superfamily ligands that regulate cell proliferation differentiation and death. Based on its essential role in TGF beta signaling pathway SMAD3 has been related with tumor growth in cancer development.