Tags: Chemical Compound, Chemical Substance.

LF22-0542 is a non-peptide bradykinin B1 antagonist. It displayed binding Ki values of 0.35 and 6.5 nM at cloned human and mouse B1 receptors respectively while having no affinity for either human mouse or rat B2 receptors at concentrations up to 10 μM. This means that LF22-0542 is at least 4000 times selective for the B1 receptor over the B2 receptor. Systemic administration of LF22-0542 inhibited acute pain induced by acetic acid formalin and a hot plate.

LF_22-0542.svg
IUPAC name
N-4-(45-Dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-26-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide

Loading...

This page contains content from the copyrighted Wikipedia article "LF22-0542"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.