Tags: Chemical Compound, Chemical Substance.

FE 200665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl) also known as CR665 is an all D-amino acid peptide that acts as a peripherally restricted κ-opioid receptor agonist. The selectivity for FE 200665 is 1/16900/84600 for the human κ μ and δ opioid receptors respectively. The dose of FE 200665 required to produce motor impairment (measure of CNS penetration) was 548 times higher than the dose required for antinociceptive activity.

FE_200665.svg
IUPAC name
(R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-N-((R)-5-guanidino-1-oxo-1-((pyridin-4-ylmethyl)amino)pentan-2-yl)hexanamide

Loading...

This page contains content from the copyrighted Wikipedia article "FE 200665"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.