Tags: Drug.

JDTic is a drug that acts as an opioid antagonist which is highly selective for the κ-opioid receptor and blocks this receptor without affecting the μ- or δ-opioid receptors. It is a 4-phenylpiperidine derivative distantly structurally related to analgesic drugs such as meperidine and ketobemidone and more closely to the μ opioid antagonist alvimopan and is structurally distinct from other κ antagonists such as norbinaltorphimine.

JDTic_cas_361444-66-8.svg
CAS number
361444-66-8
IUPAC name
(3R)-7-Hydroxy-N-[(2S)-1-[(3R4R)-4-(3-hydroxyphenyl)-34-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1234-tetrahydroisoquinoline-3-carboxamide
PubChem
9956146

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