Tags: Drug.

CI-988 (PD-134308) is a drug which acts as a cholecystokinin antagonist selective for the CCKB subtype. In animal studies it showed anxiolytic effects and potentiated the analgesic action of both morphine and endogenous opioid peptides as well as preventing the development of tolerance to opioids and reducing symptoms of withdrawal.

CI-988_structure.png
CAS number
130332-27-3
IUPAC name
4-([(1R)-2-([(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-([(tricyclo[3.3.1.137]dec-2-yloxy) carbonyl]amino)propyl]amino)-1-phenylethyl]amino)-4-oxobutanoic acid
PubChem
108186

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