Tags: Enzyme.
Hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29 HIF hydroxylase) is an enzyme with system name hypoxia-inducible factor-L-proline 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). This enzyme catalyses the following chemical reaction hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2Hypoxia-inducible factor-proline dioxygenase contains iron and requires ascorbate.