Tags: Protein.
HLA class II histocompatibility antigen DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer HLA-DO is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules this gene exhibits very little sequence variation especially at the protein level.