Tags: Chemical Compound, Chemical Substance.

Hemopressin (Hp) is an alpha hemoglobin fragment with the sequence PVNFKFLSH originally identified in extracts of rat brain using an enzyme capture technique. It binds cannabinoid receptors acting as an inverse agonist at CB1 receptors. Longer forms of hemopressin containing 2-3 additional amino acids on the N-terminus have been identified in extracts of mouse brain. These longer hemopressin peptides named RVD-Hpα and VD-Hpα bind to CB1 receptors and are agonists.

Hemopressin.svg
IUPAC name
(2S)-2-(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]-4-oxo-butanoyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid

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