Tags: Protein.
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve) YOTB Vac 1 (vesicle transport protein) and EEA1 in which it has been found. FYVE domains bind Phosphatidylinositol 3-phosphate in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function.
