List of articles in "Drug" category - Page 70

Ro 44-3888 is a non-peptidic selective and reversible glycoprotein IIb/IIIa inhibitor. It is the active metabolite of sibrafiban. It was being investigated as a treatment for heart conditions including myocardial […]

Sibrafiban (Ro 48-3657 proposed brand name Xubix) is the double prodrug of Ro-44-3888 which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following […]

Nortilidine is the active metabolite of the drug tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to […]

Sabarubicin (MEN-10755) a disaccharide analog of doxorubicin is used for the treatment of small cell lung cancer (SCLC). It has been seen to show superior antitumour efficacy which is purported […]

Cariporide is a selective Na+/H+ exchange inhibitor. Cariporide has been shown to actively suppress the cell death caused by oxidative stress.

Cryptolepine is an antimalarial drug with cytotoxic properties. It is used[citation needed] as an anticancer drug as it is able to intercalate into DNA at the cytosine-cytosine sites.

Ranbezolid is a novel oxazolidinone antibacterial. It competitively inhibits monoamine oxidase-A (MAO-A).

BMS-345541 marketed by Merck KGaA is an anti-inflammatory cell-permeable quinoxaline compound. It is an allosteric site-binding inhibitor with a primary target of IKK-2 and blocks the NF-κB-dependent transcription in mice.

Cantharidic acid is a selective inhibitor of PP2A (protein phosphatase 2) and PP1 (protein phosphatase 1).It is the hydrolysis product of the acid anhydride cantharidin.

Zolantidine is a brain-penetrating histamine H2-receptor antagonist marketed by Smith Kline and French with the research code of SK&F-95282. It is a novel benzthiazole derivative with a 30-fold higher potency […]