List of articles in "Drug" category - Page 226

Rhynchophylline is an alkaloid found in certain Uncaria species (Rubiaceae) notably Uncaria rhynchophylla and Uncaria tomentosa. It is a non-competitive NMDA antagonist (IC50 = 43.2 microM) and calcium channel blocker. […]

Remacemide is a drug which acts as a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke epilepsy Huntington’s disease […]

Lerisetron (F-0930-RS) is a drug which acts as an antagonist at the 5HT3 receptor It is a potent antiemetic and is currently in clinical trials for the treatment of nausea […]

Gacyclidine (GK-11) is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor antagonist. It is closely related to phencyclidine (PCP) and specifically is a […]

Zatosetron (LY-277359) is a drug which acts as an antagonist at the 5HT3 receptor It is orally active and has a long duration of action producing antinauseant effects but without […]

Pempidine is a ganglion-blocking drug first reported in 1958 by two research groups working independently and introduced as an oral treatment for hypertension.

Ditran (JB-329) is an anticholinergic drug mixture related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). Ditran is composed of a mixture of 70% 1-ethyl-2-pyrrolidinylmethyl-alpha- phenylcyclopentylglycolate and 30% 1-ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate. These […]

Zacopride is a potent antagonist at the 5HT3 receptor and an agonist at the 5HT4 receptor. It has anxiolytic and nootropic effects in animal models with the (R) enantiomer being […]

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.5-CT acts as a non-selective high-affinity full agonist at the 5-HT1A 5-HT1B 5-HT1D 5-HT5A and 5-HT7 receptors as well […]

Lorcaserin (APD-356 trade name upon approval Belviq expected trade name during development Lorqess) is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. […]