List of articles in "Drug" category - Page 115

Piclozotan (SUN-N4057) is a selective 5-HT1A receptor partial agonist which has neuroprotective effects in animal studies. It has been through early clinical trials in humans for treatment of acute stroke […]

Repinotan (BAYx3702) is a selective 5-HT1A receptor full agonist with high potency and efficacy. It has neuroprotective effects in animal studies and was trialled in humans for reducing brain injury […]

Ebalzotan (NAE-086) is a selective 5-HT1A receptor agonist. It was under development as an antidepressant and anxiolytic agent but produced undesirable side effects in phase I clinical trials and was […]

Sunepitron (CP-93393) is a combined 5-HT1A receptor agonist and α2-adrenergic receptor antagonist. It was previously under development by Pfizer for the treatment of depression and anxiety. It made it to […]

Lesopitron (E-4424) is a selective full agonist of the 5-HT1A receptor which is structurally related to the azapirones. In 2001 it was under development by Esteve as an anxiolytic for […]

F-15599 is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity (also known as biased agonism) by strongly activating 5-HT1A receptors in the prefrontal cortex […]

AL-1095 is a centrally-acting stimulant drug with comparable effects to amphetamine developed by Bristol in the 1970s.

Olaratumab is a monoclonal antibody which is being developed by Imclone for the treatment of solid tumors. It is directed against the platelet-derived growth factor receptor alpha.

WAY-317538 (SEN-12333) is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors. It was not the most potent compound […]