Tags: Chemical Compound, Chemical Substance.

1819-Dehydrobuprenorphine (HS-599) is a didehydro derivative of buprenorphine. It has about twice the potency of buprenorphine. It has produced a long-lasting antinociceptive response in animal tests.1819-Dehydrobuprenorphine never induced conditioned place-preference in test animals unlike buprenorphine and morphine.1819-Dehydrobuprenorphine has about three times higher affinity for the μ-opioid receptor but lower affinity for δ- and κ-opioid receptors when compared with buprenorphine.

1819-Dehydrobuprenorphine_(HS-599).svg
IUPAC name
17-Cyclopropylmethyl-45α-epoxy-6α14α etheno-7α-(1-hydroxy-122-trimethylpropyl)-6β-methoxymorphinan-3-ol

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