Tags: Drug.
ZK-93423 is an anxiolytic drug from the β-Carboline family closely related to abecarnil. It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1 α2 α3 and α5-subunit containing GABAA receptors equally. It has anticonvulsant muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor.
