Tags: Drug.
ZD6126 is a vascular-targeting agent and a prodrug of N-acetylcolchinol related to colchicine. It has shown promising results on tumors in mice.A phase I clinical trial identified gastrointestinal and cardiac effects as limiting dosing. Two phase II clinical trials were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer. ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA).
