Tags: Chemical Compound, Chemical Substance.

Zaprinast was an unsuccessful clinical drug candidate that was a precursor to the chemically related PDE5 inhibitors such as sildenafil (Viagra) which successfully reached the market. It is a phosphodiesterase inhibitor selective for the subtypes PDE5 PDE6 PDE9 and PDE11. IC50 values are 0.76 0.15 29.0 and 12.0 μM respectively.Zaprinast has also been shown to activate the orphan G-protein coupled receptor known as GPR35 both in rats and humans.

Zaprinast.svg
FDA UNII code
GXT25D5DS0
IUPAC name
5-(2-Propoxyphenyl)-1H-[123]triazolo[45-d]pyrimidin-7(4H)-one

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