Tags: Disease.
X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells. In the absence of T cell help B cells become defective. It is an x-linked recessive trait stemming from a mutated (abnormal) version of the IL2-RG gene located at xq13.1 on the X-chromosome which is shared between receptors for IL-2 IL-4 IL-7 IL-9 IL-15 and IL-21. (IL2RG).