Tags: Disease.
Wolcott–Rallison syndrome abbreviated as WRS is a rare autosomal recessive disorder with infancy-onset diabetes mellitus multiple epiphyseal dysplasia osteopenia mental retardation or developmental delay and hepatic and renal dysfunction as main clinical findings. Patients with WRS have mutations in the EIF2AK3 gene which encodes the pancreatic eukaryotic translation initiation factor 2-alpha kinase 3.