Tags: Chemical Compound, Chemical Substance.
Withaferin A is a steroidal lactone which binds to and inhibits vimentin. It was first isolated from Winter cherry (Withania somnifera). and is the first member of the withanolides to be discovered. Withaferin A is a potent inhibitor of angiogenesis (the formation of new blood vessels). Withaferin A inhibits both NF-κB and Sp1 Transcription factor activity. Withaferin A also down regulates VEGF gene expression and can affect calcium signalling.
