Tags: Protein.
The Wiskott–Aldrich Syndrome Protein (WASp) is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon Cdc42 and PIP2 acting to disrupt this interaction causing the WASp protein to ‘open’. This exposes a domain near the WASp C-Terminus that binds to and activates the Arp2/3 complex.