Tags: Protein.
In molecular biology the protein domain WHEP-TRS refers to helix-turn-helix domains. They are found in variable numbers in a particularly common protein named glutamyl-prolyl tRNA synthetase(EPRS). This protein domain has an important function in protein–protein interactions between synthetases. WHEP domains exhibit high-affinity interactions with tRNA indicating a putative evolutionary relationship to facilitate tRNA binding to fused synthetases thereby enhancing catalytic efficiency.
