Tags: Disease.
Warfarin-induced skin necrosis (or more generally coumadin-induced skin necrosis or Anticoagulant-induced skin necrosis) is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (coumarins such as warfarin).Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants.