Tags: Drug.

Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective DRI. GBR-12909 binds to the target site on the DAT ~ 500 times more strongly than cocaine[citation needed] but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels giving vanoxerine only mild stimulant effects. Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel.

Vanoxerine.png
ATC prefix
none
CAS number
67469-78-7
FDA UNII code
90X28IKH43
IUPAC name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
PubChem
3455

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