Tags: Chemical Compound, Chemical Substance.
Uvaricin is a bis(tetrahydrofuranoid) fatty acid lactone that was first isolated in 1982 from the roots of the Annonaceae Uvaria acuminata. Uvaricin was the first in a class of compounds with potent anticancer activity known as acetogenins. Acetogenins which are found in plants of the family Annonaceae seem to kill cells by inhibiting NADH dehydrogenase in the mitochondrion.