Tags: Chemical Compound, Chemical Substance.
URB754 was originally reported by Piomelli et al to be a potent noncompetitive inhibitor of monoacylglycerol lipase. However recent studies have shown that URB754 failed to inhibit recombinant MGL and brain FAAH activity was also resistant to URB754. In a later study by Piomelli at al showed that the MGL-inhibitory activity attributed to URB754 is in fact due to a chemical impurity present in the commercial sample identified as bis(methylthio)mercurane.
