Tags: Drug.
Umespirone (KC-9172) is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties. It behaves as a 5-HT1A receptor partial agonist (Ki = 15 nM) D2 receptor partial agonist (Ki = 23 nM) and α1-adrenoceptor receptor antagonist (Ki = 14 nM) and also has weak affinity for the sigma receptor (Ki = 558 nM). Unlike many other anxiolytics and antipsychotics umespirone produces minimal sedation cognitive/memory impairment catalepsy and extrapyramidal symptoms.
