Tags: Drug.
UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors acting as a weak partial agonist at the D3 subtype and an antagonist at D2Sh autoreceptors on dopaminergic nerve terminals. This causes dopamine release in the brain and has a stimulant effect as well as blocking the behavioural effects of cocaine. It was trialled for the treatment of schizophrenia but unexpectedly caused symptoms to become worse.
