Tags: Chemical Compound, Chemical Substance.
U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH2 first prepared in 1975 and acts as a thromboxane A2 (TP) receptor agonist. It potently stimulates TP receptor-mediated but not other prostaglandin receptor-mediated responses in various in vitro preparations. and exhibits many properties similar to thromboxane A2 including shape change and aggregation of platelets and smooth muscle contraction.