Tags: Drug.
TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain.It is a functionally selective μ-opioid receptor agonist developed by Trevena Inc. TRV130 elicits robust G protein signaling with potency and efficacy similar to morphine but with far less β-arrestin 2 recruitment and receptor internalization it displays less adverse effects than morphine.
