Tags: Chemical Compound, Chemical Substance.
Trimethylsilylacetylene is an acetylene molecule protected on one end by the trimethylsilyl group. It is popularly used in alkynylations e.g. the Sonogashira reaction. After desilylation (e.g. with TBAF) the ethynyl group is introduced. Using a protected alkyne as opposed to acetylene gas prevents further (undesired) coupling reactions and also has the benefit of being a liquid.This compound is commercially available.
