Trefentanil (A-3665) is an opioid analgesic that is an analogue of fentanyl and was developed in 1992.Trefentanil is most similar to short-acting fentanyl analogues such as alfentanil. In comparative studies trefentanil was slightly more potent and shorter acting than alfentanil as an analgesic but induced significantly more severe respiratory depression.
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