Tags: Protein.

Treacle protein is a protein that in humans is encoded by the TCOF1 gene.This gene encodes a nucleolar protein with an LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome a disorder which includes abnormal craniofacial development.

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