Transcription factor II Human (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH consists of ten subunits 7 of which (XPD XPB p62 p52 p44 p34 and TTDA) form the core complex. The cyclin activating kinase-subcomplex (CDK7 MAT1 and cyclin H) is linked to the core via the XPD protein Two of the subunits ERCC2/XPD and ERCC3/XPB have helicase and ATPase activities and help create the transcription bubble.
This page contains content from the copyrighted Wikipedia article "Transcription factor II H"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.