Tags: Drug.

Torreyanic acid is a dimeric quinone first isolated and by Lee et al. in 1996 from an endophyte Pestalotisopsis microspora. This endophyte is likely the cause of the decline of Florida torreya (Torreya taxifolia) an endangered species that is related to the taxol-producing Taxus brevifolia. The natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 µg/mL ranging from 3.5 (NEC) to 45 (A549) µg/mL.

Torreyanic_acid.png
ATC prefix
none
CAS number
176260-42-7
IUPAC name
(2E2'E)-44'-[(1aR5R5aS7aS8aR10aS11aS)-27911-tetraoxo-513-dipentyl-1a25a678a910-octahydro-106-(epoxymethano)bis[1]benzoxireno[34-d:3'4'-g]isochromene-7a11a(5H11H)-diyl]bis(2-met hylbut-2-enoic acid)

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