Tags: Drug.

Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a water-soluble derivative of camptothecin. It is used in form of the hydrochloride to treat ovarian cancer and lung cancer as well as other cancer types.After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15 2007 topotecan is the first topoisomerase I inhibitor for oral use.

Topotecan_Structural_Formula_V.1.svg
ATC prefix
L01
ATC suffix
XX17
Bioavailability
31.4
CAS number
123948-87-8
CAS supplemental
119413-54-6 (hydrochloride)
DrugBank
DB01030
FDA UNII code
7M7YKX2N15
IUPAC name
dihydroxy-1H-pyrano[3'4':67]indolizino[12-b], (S)-10-[(dimethylamino)methyl]-4-ethyl-49-, quinoline-314(4H12H)-dione monohydrochloride
PubChem
60700

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