Tags: Protein.
DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene.This gene encodes a DNA topoisomerase an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another thus reducing the number of supercoils and altering the topology of DNA.