Tags: Protein.
The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88 interleukin-1 receptor and the Toll receptor. It contains three highly-conserved regions and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease.
