Tags: Chemical Compound, Chemical Substance.

Tivantinib (ARQ197; Arqule) is a staurosporine derivative that binds to the dephosphorylated MET kinase in vitro. Tivantinib is being tested clinically as a highly selective MET inhibitor. However the mechanism of action of tivantinib is still unclear.Tivantinib displays cytotoxic activity via molecular mechanisms that are independent from its ability to bind MET.

Tivantinib_structure.svg
IUPAC name
(3R4R)-3-(56-Dihydro-4H-pyrrolo[321-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-25-pyrrolidinedione

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