Tags: Protein.
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex.TFPI contributes significantly to the inhibition of Xa in vivo despite being present at concentrations of only 2.5 nM.